Journal of Nutraceuticals and Food Science

Safety and Tolerability of NegEnt, a New Botanical Product Based on Liposomal Cannabidiol: A Case Series Report

The article describes a scientific study, carried out according to the case series report design involving 140 subjects, consisting of people who consumed NegEnt, an original, liposomal cannabidiol-based preparation in drops for aromatherapy, for at least one month and up to one year. The dose, taken daily, was 60 milligrams (six drops, in two pro-die administrations, of three drops each, sublingually). The study's objective was to assess the safety and tolerability of NegEnt in the medium and long term (one month and one year).

The research carried out also included a third arm, implemented according to the design of the single case research study. A volunteer, the author of this article (male, age 69), took 120 drops of NegEnt, diluted in 250 ml lowmineral water, in the early morning hours before breakfast.

The results, derived from the three arms of the research, described in the article, demonstrate the high safety and tolerability of NegEnt, confirming the literature data on cannabidiol, which demonstrate its very positive toxicological profile.

Only one adverse event, during the course of the research, was observed, at the start of treatment, in a single subject, who had previously suffered from multiple allergies and intolerances. This was a mild skin erythema, which resolved completely immediately after it was reported to the patient's doctor, who recommended discontinuing NegEnt, thereby resolving the problem.

Author(s): Tullio Scrimali

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