Vitamin B12 was found as a natural and efficient catalyst for the one-pot three-component synthesis of 4H-pyran annulated systems from the condensation between aryl aldehydes, malononitril and 1,3 dicarbonil compounds in aqueous media at ambient and thermal condition. Vitamin B12 is an organometallic compound that can play the catalytic role in the organic reactions. It has many active sites that make this catalyst affect significantly in spite of its very low amount (0.00017 g). This methodology has number of advantages such as: use of very small amount of catalyst, easy access, short reaction times, high yields, easy work up and use of non-toxic and hazardous catalyst and solvents. Although, all products were obtained just with a simple filtration and no need to column chromatography.
Mohammad Dodangeh, Malek-Taher Maghsoodlou, Mehrnoosh Kangani, Farideh Paymozd and Nourallah Hazeri
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